Research

• Pharmaceutical Biotechnology

Genetics and biochemistry of natural products biosynthesis:

• Antibiotic biosynthesis and its regulation
• Manipulation of biosynthetic genes in order to generate new analogues of bioactive molecules
• Activation of silent biosynthetic gene clusters
• Heterologous expression of antibiotic gene clusters for the discovery of novel bioactive compounds

Synthetic biology of Streptomyces:

• Engineering of Streptomyces venezuelae for terpenoid production
• Dissection of the ethanol-inducible regulatory circuit in S. venezuelae
• Construction of synthetic regulatory circuits for regulation of gene expression in bacteria in frame of the collaborative EU project StrepSynth “Rewiring the Streptomyces cell factory for cost-effective production of biomolecules” (http://www.strepsynth.eu)

Publications

• PubMed - NCBI