Phytochemistry & Biodiscovery

The enormous structural diversity of secondary metabolites from plants, fungi, microorganisms, and marine sources provides an indispensable resource for new bioactive substances and lead structures from numerous classes of compounds. In the process of early drug discovery guided by rationalized approaches natural products are investigated for their bioactivity (e.g. on cellular systems, see “Molecular Targets” group, or by our phenotypic screening platform using Caenorhabditis elegans; foto). Our research mainly focuses on the identification of novel drug leads against communicable and non-communicable diseases.

e.g.:

Mittermair E, Krenn L, Marian B. (2019) Prenylated xanthones from Metaxya rostrata suppress FoxM1 and induce active cell death by distinct mechanisms. Phytomedicine. 60, 152912. DOI.org/10.1016/j.phymed.2019.152912

Grienke U, Zwirchmayr J, Peintner U, Urban E, Zehl M, Schmidtke M, Rollinger JM (2019): Lanostane triterpenes from Gloeophyllum odoratum and their anti-influenza effects. Planta Medica 85: 159-202 DOI: 10.1055/a-0690-9236

Grienke U, Mair CE, Kirchmair J, Schmidtke M, Rollinger JM (2018): Discovery of bioactive natural products for the treatment of acute respiratory infections - An integrated approach. Planta Medica 84: 684-695 (Special Issue “Women in Natural Products Science”). DOI: 10.1055/a-0590-5153

Holzner, S., Brenner, S., Atanasov, A. G., Senfter, D., Stadler, S., Nguyen, C. H., Fristiohady, A., Milovanovic, D., Huttary, N., Krieger, S., Bago-Horvath, Z., de Wever, O., Tentes, I., Özmen, A., Jäger, W., Dolznig, H., Dirsch, V. M., Mader, R. M., Krenn, L. & Krupitza, G. (2018) Intravasation of SW620 colon cancer cell spheroids through the blood endothelial barrier is inhibited by clinical drugs and flavonoids in vitro Food and Chemical Toxicology. 111, 114-124. doi.org/10.1016/j.fct.2017.11.015

Mair CE, Grienke U, Wilhelm A, Urban E, Zehl M, Schmidtke M, Rollinger JM (2018): Anti-influenza triterpene saponins from the bark of Burkea africana. Journal of Natural Products 81: 515-523 (Special Issue in Honor of Susan Horwitz). DOI: 10.1021/acs.jnatprod.7b00774