Phytochemistry & Biodiscovery

Traditional medicinal systems all over the world have applied herbal drugs over millennia. Research based on this enormous resource creates new insights into the traditional medical systems and the elucidation of the active principles of such plants provides new bio-active compounds which can be developed for future application  in therapy.

e.g.:

Mair, CE, Grienke, U, Wilhelm, A, Urban, E, Zehl, M, Schmidtke, M & Rollinger, JM. Anti-Influenza Triterpene Saponins from the Bark of Burkea africana. Journal of Natural Products, vol 81,  pp. 515-523, 2018. DOI: 10.1021/acs.jnatprod.7b00774
Tchoupang Nana E, Reder C, Ateba SB, Zehl M, Kählig H, Njamen D, Krenn L . Acetylated Furostene Glycosides from Solanum gilo Raddi Fruits . Planta Medica: natural products and medicinal plant research, vol 83 , pp. 1227-1232, 2017 . DOI: 10.1055/s-0043-116491

Ladurner A, Zehl M. Grienke, U.; Hofstadler C, Faur N, Pereira FC, Berry D, Dirsch VD, Rollinger JM. Allspice and clove as source of triterpene acids activating the G protein-coupled bile acid receptor TGR5. Frontiers in Pharmacology, vol. 8, pp. 468, 2017 . DOI: 10.3389/fphar.2017.00468

Sheridan H, Kopp B, Krenn L, Gu, D, Sendker J. Traditional Chinese herbal medicine preparation: Invoking the Butterfly Effect. Science, vol 350, no. 6262 Suppl, pp. S64-S66, 2015. TCM_butterly.pdf