Phytochemistry & Biodiscovery

Traditional medicinal systems all over the world have applied herbal drugs over millennia. Research based on this enormous resource creates new insights into the traditional medical systems and the elucidation of the active principles of such plants provides new bioactive compounds which can be developed for future applications in therapy.

e.g.:

Oluyemi, W. M., Samuel, B. B., Kaehlig, H., Zehl, M., Parapini, S., D'Alessandro, S., Taramelli, D. & Krenn, L., (2020) Antiplasmodial activity of triterpenes isolated from the methanolic leaf extract of Combretum racemosum P. Beauv Journal of Ethnopharmacology. 247, 112203. DOI: 10.1016/j.jep.2019.112203.

Langeder J, Grienke U, Chen Y, Kirchmair J, Schmidtke M, Rollinger JM (2020): Natural products against acute respiratory infections: Strategies and lessons learned. Journal of Ethnopharmacology 248, 112298. DOI: 10.1016/j.jep.2019.112298

Tchoupang EN, Reder C, Ateba SB, Zehl M, Kählig H, Njamen D, Höller F, Glasl-Tazreiter S, Krenn L (2017): Acetylated furostene glycosides from Solanum gilo fruits. Planta Medica 83: 1227-1232 (Special Issue dedicated to Professor Dr. Max Wichtl). DOI: 10.1055/s-0043-116491

Ladurner A, Zehl M, Grienke U, Hofstadler C, Faur N, Pereira FC, Berry D, Dirsch VM, Rollinger JM (2017): Allspice and clove as source of triterpene acids activating the G-protein coupled bile acid receptor TGR5. Frontiers in Pharmacology, section Ethnopharmacology, 8: 468. DOI: 10.3389/fphar.2017.00468

Sheridan H, Kopp B, Krenn L, Guo D, Sendker J (2015): Traditional Chinese herbal medicine preparation: Invoking the butterfly effect. Science 350, 6262, S64-S66. TCM_butterly.pdf