Phytochemistry & Biodiscovery

Traditional medicinal systems all over the world have applied herbal drugs over millennia. Research based on this enormous resource creates new insights into the traditional medical systems and the elucidation of the active principles of such plants provides new bioactive compounds which can be developed for future applications in therapy.

Examples.:

Goels T, Eichenauer E, Tahir A, Prochaska P, Hoeller F, Heiß EH, Glasl S (2022): Exudates of Picea abies, Pinus nigra, and Larix decidua: Chromatographic comparison and pro-migratory effects on keratinocytes in vitro Plants; 11(5), 599. 10.3390/plants11050599

Oluyemi WM, Samuel BB, Adewumi AT, Adekunle YA, Soliman MES, Krenn L (2022): An allosteric inhibitory potential of triterpenes from Combretum racemosum on the structural and functional dynamics of Plasmodium falciparum lactate dehydrogenase binding landscape. Chemistry & Biodiversity, 19: Ahead of Print. 10.1002/cbdv.202100646

Henz Ryen A, Goels T, Steinmetz J, Tahir A, Jakobsson P-J, Backlund A, Urban E, Glasl S (2020): Bisabolane sesquiterpenes from the leaves of Lindera benzoin reduce prostaglandin E2 formation in A549 cells. Phytochemistry Letters; 38: 6-11. 10.1016/j.phytol.2020.04.015

Goels T, Eichenauer E, Langeder J, Hoeller F, Sykora C, Tahir A, Urban E, Heiss EH, Saukel J, Glasl S (2020): Norway spruce balm: Phytochemical composition and ability to enhance re-epithelialization in vitro. Planta Medica; 86: 1080-1088. 10.1055/a-1141-0921

Oluyemi WM, Samuel BB, Kaehlig H, Zehl M, Parapini S, D'Alessandro S, Taramelli D, Krenn L (2020): Antiplasmodial activity of triterpenes isolated from the methanolic leaf extract of Combretum racemosum. Journal of Ethnopharmacology; 247: 112203. 10.1016/j.jep.2019.112203

Langeder J, Grienke U, Chen Y, Kirchmair J, Schmidtke M, Rollinger JM (2020): Natural products against acute respiratory infections: Strategies and lessons learned. Journal of Ethnopharmacology; 248: 112298. 10.1016/j.jep.2019.112298