Phytochemistry & Biodiscovery

Identity and purity of the starting material are prerequisites for safety and efficacy of herbal medicinal products. For unambiguous identification and quality assessment of herbal drugs and their preparations we use robust, quick and reliable methods like HPTLC, microscopy, UV/VIS-spectrophotometry, GC, UPLC and FTIR. Sophisticated combinations of high-performance separation techniques with specific high-end detectors (e.g. GC-MS, UPLC-DAD-MSn, UPC2-PDA-QDa, UPLC-MS/MS) allow for the identification and exact quantification of very small amounts of compounds, even present in complex matrices or mixtures like plant extracts, tissues or body fluids.

e.g.:

Kussmann M, Ferth A, Obermüller M, Pichler P, Zeitlinger M, Wiesholzer M, Burgmann H, Poeppl W, Reznicek G. (2019) Compatibility of ciprofloxacin with commercial peritoneal dialysis solutions. Sci Rep. 2019 Apr 24;9(1):6512. doi: 10.1038/s41598-019-42854-y

Nikzad-Langerodi, R., Arth, K., Klatte-Asselmeyer, V., Bressler, S., Saukel, J., Reznicek, G. & Dobeš, C (2018) Quality Control of Valerianae Radix by Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) Spectroscopy. Planta Medica 84, 6-07, S. 442-448 7. doi.org/10.1055/s-0043-122239

Scheuba J, Wronski V-K, Rollinger JM, Grienke U (2017): Fast and Green – CO2 based extraction, isolation, and quantification of phenolic styrax constituents. Planta Medica 83: 1068-1075. DOI: 10.1055/s-0043-105499

Theiler, B., Glasl-Tazreiter, S., Zehl, M. & Urban, E (2017) HPTLC bioautography guided isolation of α-glucosidase inhibiting compounds from Justicia secunda VAHL (Acanthaceae) Phytochemical Analysis. 28, 2, S. 87–92