Phytochemistry & Biodiscovery

Identity and purity of the starting material are prerequisites for safety and efficacy of herbal medicinal products. For unambiguous identification and quality assessment of herbal drugs and their preparations we use robust, quick and reliable methods like HPTLC, microscopy, UV/VIS-spectrophotometry, GC, UPLC and FTIR.Sophisticated combinations of high performance separation techniques with specific high-end detectors (e.g. GC-MS, UPLC-DAD-MSn, SFC-MS, UPLC-MS/MS) allow the identification and exact quantification of very small amounts of compounds, even present in complex matrices or mixtures like plant extracts, tissues or body fluids.

e.g.:

Scheuba J, Wronski VK, Rollinger JM, Grienke U. Fast and Green – CO2 Based Extraction, Isolation, and Quantification of Phenolic Styrax Constituents. Planta Medica: natural products and medicinal plant research, vol 83, pp. 1068–1075, 2017. DOI: 10.1055/s-0043-105499

Pitschmann A, Zehl M, Heiss E, Purevsuren S, Urban E, Dirsch VM, Glasl S. Quantitation of phenylpropanoids and iridoids in insulin-sensitising extracts of Leonurus sibiricus L. (Lamiaceae). Phytochem Anal, 27, 23-31, 2016. http://www.ncbi.nlm.nih.gov/pubmed/26333151

Wiesholzer M, Pichler P, Reznicek G, Wimmer M, Kussmann M, Balcke P, Burgmann H, Zeitlinger M,  Poeppl W. An open, randomized, single-center, crossover pharmacokinetic study of meropenem after intraperitoneal and intravenous administration in patients receiving automated peritoneal dialysis. Antimicrobial Agents and Chemotherapy 2016. http://aac.asm.org/content/60/5/2790

Mair CE, de Miranda Silva C, Grienke U, Müller Kratz J, Carreño F, Zimmermann ES, de Araújo BV, Dalla Costa T,  Rollinger JM. Pharmacokinetics of hERG Channel Blocking Voacangine in Wistar Rats Applying a Validated LC-ESI-MS/MS Method. Planta Medica 2016. 10.1055/s-0042-107800