Phytochemistry & Biodiscovery

The enormous structural diversity of secondary metabolites from plants and microorganisms provides an indispensable resource for new bioactive substances and lead structures from numerous classes of compounds. Guided by rationalized approaches multi-component mixtures and pure compounds from natural sources are investigated for their bioactivity (e.g. on cellular systems, see “Molecular Targets” group, or by our phenotypic screening platform using C. elegans; foto). Our research mainly focuses on the identification of novel drug leads targeting inflammation, the metabolic syndrome, neuro-degenerative and viral diseases.

e.g.:

Grienke U, Mair CE, Kirchmair J, Schmidtke M, Rollinger JM. Discovery of bioactive natural products for the treatment of acute respiratory infection - an integrated approach. Planta Medica: natural products and medicinal plant research 2018 DOI: 10.1055/a-0590-5153

Kratz JM; Grienke U, Scheel O, Mann SA, Rollinger JM. Natural products modulating the hERG channel: heartaches and hope. Natural Product Reports, vol 34, pp. 957-980, 2017. DOI: 10.1039/c7np00014f

Grienke, U, Richter, M, Walther, E, Hoffmann, A, Kirchmair, J, Makarov, V, Nietzsche, S, Schmidtke, M & Rollinger, JM. Discovery of prenylated flavonoids with dual activity against influenza virus and Streptococcus pneumoniae. Scientific Reports, vol 6, pp. 27156, 2016. 10.1038/srep27156

Waldbauer, K, Seiringer, G, Nguyen, DL, Winkler, J, Blaschke, M, McKinnon, R, Urban, E, Ladurner, A, Dirsch, VM, Zehl, M & Kopp, B. Triterpenoic Acids from Apple Pomace Enhance the Activity of the Endothelial Nitric Oxide Synthase (eNOS). Journal of Agricultural and Food Chemistry, vol 64, no. 1, pp. 185-94, 2016. 10.1021/acs.jafc.5b05061